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Three derivatives spectrophotometric methods have been described for the assay of amoxycillin in urine. The methods were based on the amplitude measurements of second derivative (D2), first derivative difference (delta D1) or second derivative difference (delta D2) curves. These values were linearly correlated to the amoxycillin concentration in the range of 0.2-1.0 mg% with negligible intercepts. The absolute recovery from urine specimens was found to be 98%. The within-day and between-day precision were satisfactory.

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Faculty of P h a r m a c y -U n i v e r s i t y of Alexandria,El Mesallah 2 1 5 2 1 ,Alexandria, E G Y P T - A B S T R A C TA n isocratic, sensitive high-performance 1 iquid chromatographic method has been developed for the determination o f phenobarbitone, methylphenobarbitone and phenytoin in tablets. A reversed-phase octadecylsi lane column, 10 pm, was utilized with a mobile phase consisting o f 45% methanol, 55% water and 0.5 m l glacial acetic acid at a flow rate of 1.8 mllmin. The samples were dissolved in methanol containing diethylbarbituric acid as an internal standard. Quantitation was achieved with UV detection at 240 n m and b y the measurment o f the peak a r e a r a t i o . 2215 Copyright 0 199 1 by Marcel Dekker, lnc. Drug Dev Ind Pharm Downloaded from informahealthcare.com by University of British Columbia on 11/20/14 For personal use only. Drug Dev Ind Pharm Downloaded from informahealthcare.com by University of British Columbia on 11/20/14For personal use only.