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Available online xxxx AMS 2000 subject classifications: 62K05 62K15 Keywords: Mixture discrepancy criterion Foldover plan Foldover design Combined design Balanced design Lower bound a b s t r a c t Mixture discrepancy criterion (Zhou et al., 2013) is more reasonable than other discrepancies criteria for measuring the uniformity of experimental designs. In this paper, we take the mixture discrepancy criterion as the optimality measure to assess optimal foldover plans, which serve as benchmarks for constructing optimal foldover and combined designs (see Definition 2). New analytical expressions as well as new lower bounds of the mixture discrepancy criterion for both symmetric two-level and three-level combined designs under general foldover plans are obtained. We also describe necessary conditions for the existence of optimal combined designs meeting these lower bounds. An algorithm for searching the optimal foldover plans is also developed. Illustrative examples are provided, where numerical studies lend further support to our theoretical results. These results may help to provide some powerful and efficient algorithms for searching the optimal foldover and combined designs.

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