The spread of dermatophytosis among animals and humans in the localities of Ukraine in particular in the city of Kharkiv is due to the presence of range of the most susceptible animals. This information mainly concerns dogs and cats that can be affected by dermatophytosis and may be a reservoir of dermatophyte fungus. Particularly important is that domestic dogs and cats represent a significant epidemiological threat to the population. The purpose of the research was to monitor the morbidity of dermatophytosis in domestic dogs and cats in Kharkiv. Diagnostic studies of dermatophytosis morbidity level determination in domestic dogs and cats were performed complexly including the clinical and epizootic data, microscopic and mycological laboratory tests conducted according to generally accepted methods (Kovalenko et al., 2017; Sutton, Fothergill and Rinaldi, 2001). Dermatophytosis was diagnosed among 231 animals in the study of 1,277 domestic dogs kept by the inhabitants of the city of Kharkiv which was in 18.09% of samples. Dermatophytosis was also detected in 615 animals which constitutes 50.25% in the study of 1,124 cats. The cultures of dermatophytosis agent Microsporum canis were isolated from 126 dogs (18.98%) and 110 cats (40.74%). Trichophyton mentagrophytes cultures were isolated from 16 dogs (2.41%) and 16 cats (5.93%). The percentage of isolated cultures of mold and yeast-like fungi in the studies of sick dogs and cats were 38.55% and 22.25% respectively. Obtained results indicate quite high level of the dermatophytosis spreading among domestic dogs and cats in the city of Kharkiv.

Kuzmenko, M.V. (2019). Epizootological monitoring of the circovirus and parvovirus infections and the reprodactive and respiratory syndrome in pigs in the SouthEast region of Ukraine.

Infectious pathology of pigs in the region is represented mainly bacterial diseases (52,8% of the total infectious diseases). However, the bacteria, as is usually secondary pathogens to cause clinical picture against viral disease. Among the latter occupies a special place reproductive and respiratory syndrome, characterized by obstetric and gynecological diseases in sows and respiratory problems in piglets. More and more reports have appeared in the world literature of the recent years, indicating the widespread distribution of the porcine reproductive and respiratory syndrome in North America and Europe. Currently, two types of virus are identified from pigs-the North American and European. PRRS is widespread also in Ukraine. The incidence in individual farms may exceed 55%, while the mortality observed in 2-6-month-old pigs varies from 1 to 25%. A serious decline in the growth and development of piglets is present. Viral diseases are one of the main causes of reproductive disorders in sows. The reproductive and respiratory syndrome (PRRS) is one of such diseases. That is why it is important to quickly and reliably determine the cause of the diseases in animals. A successful prevention of viral infections, which forms the basis of etiology of reproductive disorders, is dependent on an in-depth study of the nature of the viruses, antigenic and biological properties of their components, mechanisms of their relationship with cells, pathogenesis, factors of specific and nonspecific immunity as well as possible associations. The purpose of our research was a detailed study of the epizootic situation regarding the reproductive and respiratory syndrome of pigs in farms of different forms of ownership in the Chernukhinsky district of the Poltava region. In order to determine the role and place of PRRS in the infectious pathology of pigs in the conditions of the Chernukhinsky district of the Poltava region, we have examined the nozological profile, density, geographical distribution and annual dynamics of infectious diseases in

The article presents the results of experimental studies of the sorption and disinfecting properties of the drying agent for layer dryer "Mikadez" TU U 08. 1 -36613759 -002: 2013 in vitro for standard test -cultures of microorganisms (Echerichia coli, Staphilococcus aureus).It is known that the increased moisture content of the litter leads to disruption of biothermal processes and the development of pathogenic, anaerobic and putrefactive microflora in it, contributes to contamination with various pathogenic microorganisms, affects the health and productivity of poultry, the yield and quality of products.The experiments were carried out in the Scientific Laboratory of Molecular Genetic Research Methods. P.I. Verbitsky Department of Epizootology and Veterinary Management of the Kharkov State Zooveterinary Academy using generally accepted microbiological methods. The sensitivity of microorganisms of the standard test -cultures of Echerichia coli, Staphilococcus aureus to the drug "Mikadez" was determined by the disco -diffusion method.According to the research results, it was found that the dryer "Mikadez", which contains mineral and plant adsorbents has sorption properties and negatively affects the development of test cultures of microorganisms. The effect of the drug on microbial cells is due to the effect of active substances (nanodispersed amorphous silicon dioxide and other minerals of the complex) on glucoprotein structures and phospholipids of membranes, surface receptors of microorganisms, which leads to a detrimental effect on the development and viability of microorganisms of standard test cultures Echerichia coli and Staphilococcus aureus, the drug also has a pronounced sorption effect (bacagglutination) on G + and G-microorganisms, in which its antiseptic and disinfecting properties are manifested. The zone of growth inhibition of standard test -cultures by the disc -diffusion method was 17-20 mm.

Relevance of the topic. Infectious feline rhinotracheitis, like herpesvirus infection is an acute disease characterized by damage to the eyes and respiratory system. Cats of all breeds are ill regardless of age. Kittens can become infected from mothers carrying the virus. In small populations of healthy animals the prevalence of the virus is less than 1 %, while in large populations it can reach 20 %. In shelters, the risk of contamination and infection is higher - up to 50 %. Almost all animals with primary infection become latent carriers throughout their lives. The incidence can reach 55%, the mortality rate is 5 – 25 %. The causative agent - a DNA-containing virus has a tropism for the epithelial cells of the mucous membranes of the nasal cavity, tonsils, trachea, conjunctiva. Diagnostic methods for detecting latent carriage have not yet been developed, since the virus remains in the form of genomic DNA in the nucleus of latently infected neurons without replication. Laboratory diagnosis of feline rhinotracheitis is currently most often performed by isolating the pathogen or by PCR using swabs from the oral cavity and conjunctiva. The PCR method allows detecting the virus and is the laboratory “gold standard” of diagnostics. Antibodies to the pathogen can be detected using a neutralization test or ELISA in serum, conjunctival mucus and cerebrospinal fluid. Direct methods for diagnosing herpesvirus infection in chronic or latent course have not been developed. For the treatment of viral diseases of small pets, immunomodulators are widely used, which stimulate the immune system. Some drugs tend to induce the production of its own interferon in the body. However, their use often does not give a therapeutic effect due to the peculiarities of the pathogenesis of the disease and the replication of the pathogen. To date, preparations based on the species-specificity of feline interferon have not been available on the domestic market, and attempts to use human interferon for the treatment of viral infections in cats have not yielded the expected result with prolonged and repeated courses due to the formation of neutralizing antibodies in the animal's body.