In this prospective multicenter trial of chest pain patients without known CAD, 64-multidetector row CCTA possesses high diagnostic accuracy for detection of obstructive coronary stenosis at both thresholds of 50% and 70% stenosis. Importantly, the 99% negative predictive value at the patient and vessel level establishes CCTA as an effective noninvasive alternative to ICA to rule out obstructive coronary artery stenosis. (A Study of Computed Tomography [CT] for Evaluation of Coronary Artery Blockages in Typical or Atypical Chest Pain; NCT00348569).

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Every individual, every municipality, every province, as well as our Federal Government, has a special duty in this crusade to fight a disease which has attacked over one-half of our homes. By increasing the efficiency of the means now at our disposal, by the introduction of such measures where now none obtain, and by earnest, active, aggressive work of education our large annual mortality should soon show a maarked decrease.-THE SIGNIFICANCE OF SOME ENLARGEMENTS OF THE THYROID GLAND.* BY A. F. MARTIN, M.D.MANCH., CH.B.VICT., LATE HOUSE-PHYSICIAN, NOtLTE STAFFORDSHIRE INFIRMARY AND EYE HlOSPITAL. * Read before the Staffordslhire Branch of the British Medical Association, being extracts from a thesis for the degree of M.D. of the Victoria University of Mfanchester.