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A527tools were designed for, or used in, more than 25 different mental disorders. The most diversity was found for affective disorders, with 44 tools for depression, 36 for anxiety, 16 for any affective disorder, 13 assessing mood, 8 for phobias and 7 for obsessive-compulsive disorder. Forty two tools were used for substance abuse or addictions, 41 each for dementia and stress/PTSD, 40 for schizophrenia, 16 for ADHD, 17 for eating disorders, 10 for delirium and 7 for bipolar disorder. ConClusions: A vast number of different PRO tools have been developed and used in research published over the past 10 years. Mental disorders have been the most widely represented, reflecting their impact on subjective outcomes, but the diversity makes it challenging to compare effectiveness and cost-effectiveness outcomes across studies.