Xanthomas are benign tumor-like lesions, composed of accumulation of foamy lipid-laden histiocytic cells. Usually, xanthomas appear in the skin and tendons, while visceral location is uncommon. These lesions can be found anywhere along the gastrointestinal tract, commonly in the stomach and colon.Esophageal xanthoma (EX) is exceedingly rare lesion which can be incidentally found during endoscopy. A few case reports of EX from 1984 up to now have been reported. We present the first case of EX in Barrett's esophageal mucosa on the background of non-steroidal anti-inflammatory drugs use.