The intestinal microflora of the human body performs vital regulatory functions. In the course of the study, a biotechnological complex has been developed in the form of dietary supplements, the functional properties of which are aimed at regulating the intestinal biocenosis, inhibiting pathogenic and conditionally pathogenic microflora, as well as developing a useful part of the microbiota. The qualitative and quantitative composition of the specialized product includes, mg/5.5 g, floration (soluble dietary fiber) - 1,375 (1,238); metafiltrates Bifidobacterium bifidum - 620, Bifidobacterium breve - 600, Lactobacillus delbrueckii - 500, Hericium coralloides - 242.5, Propionibacterium freudenreichii - 100; lactulose (50 %) - 400; postbiotic metafiltrate Subtizym - 200; silicon dioxide - 30; endofulvin (Endofulvin, humic acids) - 9.62 (7.5); chitosan - 5; para-aminobenzoic acid - 2; nicotinamide (vitamin B) - 1.81 (1.8); cysteine - 1.25; calcium pantothenate (vitamin B) - 0.654 (0.6); riboflavin (vitamin B) - 0.16. An innovative feature of the production technology is a liquid concentrated form of dietary supplements, which ensures rapid passage through the stomach, the preservation of active principles and the effectiveness of the implementation of specified functional properties. The organoleptic, microbiological and physicochemical indicators of quality and safety have been studied, the results of which make it possible to determine the regulated characteristics and shelf life - 1 year at the temperature of 0-25 °C, relative humidity of not more than 60 %. The developed complex is recommended for use in the amount of 5.5 g of concentrate 3 times a day; course duration - 1 month. The product has passed production tests at ArtLife LLC (Tomsk).

The article deals with the issues of biotechnological strategies for eff ective nutritional support of intestinal microflora and health by means of specialized products in the form of dietary supplements with directed functional properties. Clinical evidence of the effi cacy of the developed program is presented.