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The aim of the study was to test an innovative implant made of the urethane bone-replacing material Rekost-M using 3D technologies for customized reconstruction of post-craniotomy skull defects. Materials and Methods. To study the properties of the bone replacement material Rekost-M, physical, mechanical and toxicological tests, as well as preclinical studies on fibroblasts cultures and lab animals (rabbits) were carried out. Clinical evaluation of the developed implant was conducted within a multicenter trial. Results. The replacement of post-craniotomy skull defects with implants made of the bone replacement material Rekost-M represents a reliable method of cranioplasty. Using 3D technology allows for modeling of individual implants of any complexity.

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