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Pathomorphological changes and disturbances in the integrative activity of the central nervous system of rats are studied after bilateral compression ischemia of the frontal cortex. Bilateral compression of the frontal cortex is shown to result in the formation of limited foci of ischemic necroses in the cortex, which are surrounded by the perifocal zone. This is attended by reduced horizontal motor activity in the "open field" test, as well as by a reduced latency of the conditioned passive avoidance response. The motor activity of operated animals is restored on day 14 postoperation, correlating with regeneration of some damaged neurons in the perifocal zone, whereas the latency of the conditioned passive avoidance response remains markedly reduced.