Health of Kyzylorda region dwellers is influenced by following negative factors: physical — climate (sharply continental dry hot climate, winds, high solar radiation); chemical — biochemical components in water, soils, ambient air, radiation background; anthropogenic — overregulated river-bed of Syrdaria, insiccation of Aral sea, oil extraction, uranium ores extraction, etc.Findings are that the maximal respiratory diseases prevalence is seen in a region neighboring toAral sea. Kyzylorda region used to take 3rd place in the republic for average longstanding mortality with respiratory diseases. High morbidity in Zhalagashsky and Zhanakorgansky districts, high mortality with respiratory diseases in Kazalinsky and Zhanakorgansky districts are seen in regions situated far fromAral sea.