Annotation. The work presents a clinical and histological description of a case of glomuvenous malformation and a review of modern data on the diagnosis and treatment of this disease. A case of diagnosis of glomuvenous malformation on the foot of the right lower limb in a 46-year-old man was analysed. The case was characterized by an uncertain dermatological status with the need to exclude malignant neoplasia of the skin. Considering doubts about the benign nature of the skin lesion, the patient was recommended to undergo a therapeutic and diagnostic biopsy. After a medical-diagnostic biopsy, histological sections showed skin with moderate hyperparakeratosis of the epidermis and a clearly delineated, non-encapsulated formation in the dermis. The tumour is represented by numerous vascular channels of the venous type of small and medium caliber, some of which have an enlarged lumen and a thickened wall, filled with erythrocytes. Clusters, chains, and fields of monomorphic glomus cells with weakly expressed eosinophilic cytoplasm and rounded nuclei with finely dispersed chromatin are located perivascularly, without atypia. Mitotic figures are absent. The intercellular stroma is sclerosed with focal oedema. Considering the results obtained by us and the data of modern studies, we can state the ambiguity of views on the diagnosis of glomuvenous malformation with the need for more aggressive diagnostic and therapeutic tactics in adults. The development of an algorithm for the management of adult patients with glomuvenous malformation of the skin is a prospect for further research.

Annotation. Spitz nevus is a difficult issue in the diagnosis of skin tumors and in the clinical tactics of management of patients with this disorder. The case of diagnosis of Spitz's nevus in patient R., born in 1978 is given. in which a dermatologist's examination revealed skin tumors on the torso and extremities. Spitz's nevus was suspected. Dermatological status: on the skin of the face, neck, torso and extremities there are spots and papules, up to 6 mm (number 62) maximum, light and dark brown, without signs of inflammation, irritation and trauma. Dermatoscopic picture of pigment formations is represented by melanocyte, non-melanocyte and halo nevi. On the skin of the left breast there is a melanocyte formation asymmetric in shape in the horizontal axis, dermatoscopically corresponding to the Spitz nevus (dark brown unstructured area in the center, illuminated to the periphery with large brown granules and dots located on the periphery of the focus in the form of rays 3.8. A biopsy was performed. Histologically, there is skin with acanthosis and minor hyperortokeratosis, located in the basal layer of symmetrical, well-defined formation with refractive artifacts. The tumor is formed by vertically placed junctional nests of mainly spindle-shaped, as well as epithelioid multinucleated melanocytes with eosinophilic cytoplasm, moderate polymorphism of vesicular nuclei. The latter have numerous prominent small basophilic nucleoli. Mitotic figures and pegetoid growth are absent. Perivascular lymphocytic infiltrates are present in the papillary layer of the dermis. The patient was diagnosed with Nevis Spitz. It is recommended to monitor dynamically with dermatoscopy once a year, to avoid hyperinsolation, the use of sunscreen with SPF factor. The problem of diagnostic and treatment tactics of a patient with Spitz's nevus remains a difficult problem today. Further study of the peculiarities of Spitz's nevus in adulthood seems promising.