Alcohol-water extracts of Thymus vulgaris have obtained by ultrasonic extraction method for different times extraction. The obtained extracts have been tested for the quantitative content of extractive substances, phenolic compounds and flavonoids and for the presence of antioxidant activity. The best studied indicators were found in extract obtained by ultrasound extraction for 40 minutes (content of extractive substances 25 mg / ml, sum of polyphenolic compounds 30 mg / ml, flavonoids content 45 mg / ml).

The analysis of the range of drugs containing raw materials and biologically active compounds Pinus sp. registered in Ukraine and found: most drugs are presented in the form of ointments; the predominant share of the range (79%) of the studied drugs are multicomponent drugs; the share of the range of drugs manufactured at pharmaceutical enterprises of Ukraine is 38%; the largest number of drugs is manufactured by domestic manufacturers in the city of Zhytomyr PJSC "Liktravy" and LLC "DKP" Pharmaceutical Company; among importing countries, Germany dominates, followed by India and Estonia, respectively.

Drugs of group R01, according to the АTC- classification used in the treatment of diseases of the nasal cavity by composition and dosage form, were studied. The dependence of the therapeutic effect of drugs on the chemical structure of the active substance, possible combinations of active substances belonging to different pharmacological groups (sympathomimetics, corticosteroids, and antihistamines), which determine their specific effect on the human body, are analyzed. These active substances are found in both mono- and multi-component drugs. In combination drugs, other compounds of natural and synthetic origin are also used to enhance the therapeutic effect.