Introduction: MDR-TB poses a significant challenge to global management of TB. Laboratories in many countries among which include Nigeria are unable to evaluate drug resistance, and clinical predictors of MDR-TB might help target suspected patients.Method: The study was a cross sectional study design. Multistage sampling technique was employed in the selection of 403 tuberculosis patients. Data were analyzed using SPSS version 25. Level of significance was set at P<0.05.Results: Fifty three 53 (13.2%) of the total respondent had MDR-TB compare to national prevalence of 8% which is steeper among males 36(67.9%) (p>0.05). Education and Occupation shows a significant association with MDR-TB, (÷2=24.640, p = 0.007) and (÷2=14.416, p=0.006) respectively, smoking (r=0.074, p<0.05) and alcohol consumption (r=0.083, p>0.05) show no significant association with occurrence MDR-TB.Conclusion: Previous TB treatment and Adherence with treatment regimen were found to be the major risk factor for MDR-TB. Targeted educational intervention for patients and their contacts may minimize the non-adherence with prescribed TB treatment and lessen MDR-TB magnitude. Key words: TB Patients, MDR-TB, tuberculosis, risk factors.

Introduction: In Nigeria, patients accessing Directory Observed Therapy (DOTS) treatment are exposed to resistance to anti-TB drugs, hence is  considered a priority, only few studies have focused on the relevant risk factors, Factors leading to development of drug resistance need to be understood to develop appropriate control strategies for national programsMethod: The study was a cross sectional study design. Multistage sampling technique was employed in the selection of 403 tuberculosis patients in Ibadan North Local Government Area of Oyo State. Data were collected using self-administered structured questionnaire, and analyzed using SPSS version 25. Level of significance was set at P<0.05.Results: Fifty three (13.2%) of the total respondent had Multidrug Resistant TB (MDR-TB) which is more among the males 36(67.9%) (p>0.05). Education and Occupation shows a significant association with MDR-TB, (χ2=24.640, p =0.007) and (χ2=14.416, p = 0.006) respectively,risk factors such asprevious TB treatment and Adherence with treatment regimen (r=0.270, p<0.05), HIV (r=0.168, p<0.05) and smoking (ß=0.107, t=2.144, p<0.05) were statistically associated with development of acquired MDR-TB.Conclusion: This finding revealed that Previous TB treatment andAdherence with treatment regimen were found to be the major risk factor for MDR-TB. Targeted educational intervention for patients and their contacts may minimize the nonadherence with prescribed TB treatment and lessen MDR-TB magnitude. High quality directly observed treatment should be strengthened to ensure that the previously treated patients can receive standard and regular regimens. Keywords: TB Patients, MDR-TB, tuberculosis, Risk factors.   French Title: Facteurs de risque associés à la MDR-TB parmi les patientstuberculeux à Ibadan, état d'Oyo, Nigéria Introduction: Au Nigéria, les patients accédant au traitement DOTS (Directory Observed Therapy) sont exposés à une résistance aux médicaments  antituberculeux, ce qui est considéré comme une priorité, seules quelques études se sont concentrées sur les facteurs de risque pertinents. Les facteurs menant au développement d'être compris pour développer des stratégies de contrôle appropriées pour les programmes nationaux.Méthode de l'étude: L'étude était un plan d'étude transversale. Une technique d'échantillonnage à plusieurs degrés a été utilisée pour  sélectionner 403 patients tuberculeux dans la région du gouvernement local d'Ibadan Nord de l'état d'Oyo. Les données ont été collectées à l'aide d'un questionnaire structuré auto-administré et analysées à l'aide de la version 25 du SPSS. Le niveau de signification a été fixé à P <0,05.Résultats de l'étude: Cinquante-trois (13,2%) des répondants totaux avaient une tuberculose multi résistante (MDR-TB), ce qui est plus parmi les hommes 36 (67,9%) (p> 0,05). L'éducation et la profession montrent une association significative avec la TB-MR, (χ2 = 24,640, p = 0,007) et (χ2 = 14,416, p = 0,006) respectivement, des facteurs de risque tels que le traitement antituberculeux antérieur et l'observance du schéma thérapeutique (r =0,270, p <0,05), le VIH (r = 0,168, p <0,05) et le tabagisme (ß = 0,107, t = 2,144, p <0,05) étaient statistiquement associés au développement de la TB-MR acquise.Conclusion: Ce résultat a révélé que le traitement antituberculeux antérieur et l'observance du schéma thérapeutique étaient les principaux  facteurs de risque de TB-MR. Une intervention éducative ciblée pour les patients et leurs contacts peut minimiser la non-observance du traitement antituberculeux prescrit et réduire l'ampleur de la TB-MR. Un traitement de haute qualité directement observé doit être renforcé pour garantir queles patients précédemment traités puissent recevoir des schémas standards et réguliers. Mots-clés: Patients TB, MDR-TB, tuberculose, facteurs de risque

Background: The global pandemic of tuberculosis has left everlasting scars on people’s lives. Drug-resistant tuberculosis is becoming an increasingly serious hazard to public health. With over 240,000 fatalities due to drug-resistant tuberculosis (DR-TB) worldwide, and Nigeria is one of the 14 nations with a significant multi-drug resistant TB burden, increased focus on dis-ease control is needed. Methods: The study was a retrospective cohort study. A total of 149 patients diagnosed using the gene Xpert machine and referred to the DR-TB treatment centers in University College Hospital and Government Chest Hospital were recruited. Data were collected from the patients’ case files and analyzed using Statistical Package for Social Sciences (SPSS) version 25. Results: One hundred and forty-nine MDR-TB patients were enrolled in the study, of which 12.75% were new cases while 130 (87.2%) were on retreatment. The prevalence of MDR TB mortality was 4%. However, 30.9% had normal PCV at baseline while 68.5% of those enrolled had abnormal PCV. A total of 22(14.8 %) were reactive to the HIV test, while 125(83.9%) were not. At baseline, Body Mass Index (BMI) showed that 16.1% had a healthy weight, 18.1% were underweight, 2.7% were over-weight, and 59.7% were obese. At four months of treatment, BMI shows that 59.1% had healthy or normal weight, 12.8% were underweight, 6.0% were overweight, and 0.6% were obese. At four months, a significant association was observed between the baseline PCV, HIV status, hypertensive state, and the MDR-TB patient’s treatment outcome (p < 0.05). Conclusion: The category of MDR TB patients had a significant outcome in the patient’s survival. New patients on treatment had better survival outcomes than retreatment cases. The baseline PCV and HIV status had a significant impact on the treatment outcome of the MDR-TB patients at four months of treatment TB. Also, good care needs to be intensified in MDR-TB patients that have HIV so as to improve the treatment outcome of such patients.