ALVES-DO-PRADO W, CORRADO AP, PRADO WA. Reversal by atropine of tetanic fade induced in cats by antinicotinic and anticholinesterase agents. Anesth Analg 1987;66:492-6. The tetanic fade induced by intraarterial adtninistratioiz of neostipiiie or by subparalyzing doses of d-tubocurarine or /zexariit~thoriiuiii zuas studied in cat anterior tibial muscle p r e p ra t io n s . The prior adm in is t ra t ion of atropine sign ificarztly reduced the time for recovery from the tetanic fade induced by the abozie nzenfioned drugs. A similar response zim seeti udzen atropine was adniinistered prior to neostig rnine adniinistration for reziersal of paralyziiig doses of d-tubocurarine. We interpret these results to slioul that presynaptic inuscarinic receptors participate in a negntizie feedback affecting acetylcholine release at the neiiroiniis~iilnr junction.

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