In this study, lipase-mediated dynamic kinetic resolution (DKR) of various benzylic amines (1a−g) is presented which is realized in a so far unprecedented fully continuous-flow system. The DKR process applying sol−gel immobilized lipase B from Candida antarctica as biocatalyst, palladium on 3-aminopropyl-functionalized silica as racemization catalyst, isopropyl 2ethoxyacetate as acylating agent, ammonium formate as hydrogen and nitrogen sources, and 2-methyl-2-butanol as solvent under regulated pressure provided the desired products in moderate to good yields with excellent enantiomeric excesses.

A procedure is described for the preparation of highly branched ketones and alcohols with the general formulae R2R3R4C.CH R5*CO-R1 and R2R3R4C-CH R6*CR6(OH) R l. The multi-step route involves classical synthetic methods which give good yields. R may be varied and can be either alkyl or aryl.