Objective: To present a clinical observation of a patient with pseudomembranous colitis (PMC) complicated with multiple colon perforations, and of post-surgery recovery. Key Points. Severe PMC can cause complications, such as toxic dilatation and perforation on colon, requiring emergency surgery. Clinical observation demonstrates the advisability of extended surgery for a patient with PMC complicated with perforations. Conclusion. PMC is a dangerous disease; a severe disease can cause colon perforation and require emergency surgery. Near-total colon excision in perforation in patients with PMC is justified and a most advisable type of surgery. Keywords: pseudomembranous colitis, multiple perforations, general peritonitis.