Natural products are vital in drug discovery and the search for anticancer agents has been significant importance to the researchers for a long time. In the present study, aqueous leaf extract of Pouteria sapota (P.sapota) was evaluated for its cytotoxic activity. The leaf extract was preliminarily screened for antioxidant activity using DPPH method for Radical Scavenging Activity, Hydrogen Peroxide Scavenging Activity and Reducing Power Activity. Further, the aqueous leaf extract was screened for cytotoxic activity against breast cancer cell lines (MCF-7) in vitro. The results of the study showed that aqueous extract of the P.sapota leaf was rich in phytochemicals, antioxidant activity and showed a significant anti-cancer activity against tested MCF-7 cell lines. The present study was designed to evaluate the anticancer potential of P.sapota leaf. The antioxidants present in P.sapota have strong cytotoxic activity suggests that it can be considered for anti-cancer treatment.

The idea behind this study is to investigate the controllability of dynamical systems in terms of the ψ-Caputo fractional derivative. The Grammian matrix is used to get at necessary and sufficient controllability requirements for linear systems, which are characterized by the Mittag-Leffler functions, while the fixed point approach is used to arrive at adequate controllability criteria for nonlinear systems. The novelty of this research is to inquire into the controllability concepts by utilizing the ψ-Caputo fractional derivative. Since ψ-Caputo fractional derivatives have the advantage of capturing memory effects as well as increasing the accuracy of anticipating real-world scenarios. A few numerical examples are offered to help better understand the theoretical results.

In this article, we study the reachability of linear and non-linear fractional dynamical systems with multiple delays in control in the sense of the ψ-Hilfer pseudo-fractional derivative. The necessary and sufficient conditions for the reachability of linear fractional dynamical systems are obtained using the Gramian matrix, which is expressed by Mittag–Leffler functions. Sufficient conditions for the reachability of nonlinear fractional dynamical systems are obtained by using Schauder’s fixed point theorem. Two numerical examples are offered to help better understand the theoretical results.

This research investigates the controllability of linear and non‐linear fractional dynamical systems with distributed delays in control using the ‐Caputo fractional derivative. For controllability of linear systems, the positive definiteness of Grammian matrix, which is characterized by Mittag–Leffler functions, is used to provide necessary and sufficient conditions. For the controllability of non‐linear systems, the iterative technique with the completeness of is used to obtain sufficient conditions. Using the ‐Caputo fractional derivative, this study is new since it investigates the ideas of controllability. A couple of numerical results are offered to explain the theoretical results.

The recent global outbreaks of the ZIKA Virus (ZIKV) reported in 85 countries and territories caused severe complications such as microcephaly among neonates and Guillain-Barre Syndrome among the older population. Recently, an outbreak of ZIKV was reported from Thiruvananthapuram, the capital city of Kerala, India with 66 cases being reported so far. We conducted an outbreak investigation and the primary findings are described here. A cluster of ZIKV cases from the Kadakampalli / Anamugham administrative wards of the Thiruvananthapuram Municipal Corporation area was reported where Kerala Institute of Medical Sciences (KIMS) is located. Later many ZIKV cases were reported from other wards of the city. The density of known Aedes vectors was high in this region of the metropolitan city. Aedes albopictus, Aedes aegypti and Aedes vittatus collected from the focal area of the outbreak were found to be naturally infected with ZIKV. Male specimens of Ae. albopictus were naturally infected, indicating trans-ovarian transmission of the virus. This is first report of incrimination of Ae. albopictus and Ae. vittatus in ZIKV transmission from India. The virus was characterized and the partial sequences clustered with the Asian strain of ZIKV reported from India. The NS5 sequences of human and Ae. albopictus pools from Thiruvananthapuram were 100% similar indicating an ongoing active ZIKV transmission. The state health authorities were sensitized and appropriate containment and vector control measures have been initiated to contain the outbreak. This report underscores the importance of continued human and vector surveillance as well as genomic sequencing to understand the virus evolution and implications on public health.