The leaves of Pluchea symphytfolia (Miller) Gilis (Asteraceae) are used by the Mixe indians (Oaxaca, Mexico) against stomach-ache, diarrhea, intestinal parasites, and externally against infections of the ear (1). Only sesquiterpenes derived from cuauthemone and thiopheneacetylenes have been isolated from this species (2). Guided by a gelatine precipitation assay, the new 1,3,4,5-tetracaffeoylquinic acid (1) and compound 2 were isolated from the EtOAc layer of an aqueous acetone extract of the air-dried aerial parts in yields of 0.3% and 0.1%, respectively. Their separation was achieved by CC on Sephadex LH-20 and on MCI-CHP 20 HP gel. The structures of 1 and 2 were established by 1H-NMR and 13C-NMR spectroscopy, including 2Dhomo and 2D-hetero NMR techniques, mass spectrometry, and by chemical degradation.

Palabras clave:  Enfermedad de Lyme Eritema crónico migrans  Tratamiento  Parálisis facial Resumen Lyme disease: report of two casesLa borreliosis de Lyme es una enfermedad multiorgánica con afectación principalmente dermatológica, reumática, neurológica y cardiaca. La detección y el tratamiento en los primeros estadios son básicos para evitar su progresión. El pediatra, por tanto, debe conocer las manifestaciones clínicas de la enfermedad, así como establecer un correcto diagnóstico y tratamiento.Se exponen dos casos que incluyen las formas más frecuentes de presentación.Lyme borreliosis is a multisystem disease mainly dermatological, rheumatical, neurological and cardiological. The detection and treatment in the early stages are essential to prevent its progression. The pediatrician, therefore, must be aware of the clinical presentations of the disease as well as to establish a correct diagnosis and treatment.Two cases are presented involving the most common forms of presentation. La distribución de esta garrapata a nivel mundial hace de la borreliosis de Lyme una enfermedad asociada a áreas forestales de hoja caduca del he-

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