In the presence of 0.2 mol of aqueous KOH to 1 mol of the initial salt dialkyl(2-butynyl-4-hydroxy)-(3-R 1 -propargyl)ammonium salts (R 1 = Ph, vinyl, or isopropyl) undergo cyclization, forming 2,2-dialkyl-4-hydroxymethylisoindolinium and 2,2-dialkyl-4-hydroxymethylbenzo[f]isoindolinium salts [1][2][3].While studying the question of the stability of the above-mentioned salts under the conditions of aqueous alkaline cleavage we discovered intramolecular recyclization, which included a stage with cleavage of the isoquinoline ring by the action of the alkoxide ion formed in the alkaline medium and the formation of a dihydrofuran ring [2][3][4][5]. It was established that the recyclization process was facilitated by increase in the number of aromatic rings and by the presence of a methyl substituent in the benzene ring. Thus, heating of the reaction mass for only 40-60 min is required for the recyclization of benzo[5,6;5′,6′-a,c]di[2,2-dialkyl-4-hydroxymethyl]isoquinolinium [5].In order to investigate further the effect of the structure of the initial salts on their cyclization and the subsequent recyclization of the obtained products and also to obtain new potentially active isoindolinium R 2 N Cl O H R 2 N OH R 1 1a-c 2a-c 1a-c R 1 = C 6 H 4 Cl-p, 1, 2 a R = Pr, b R 2 = (CH 2 ) 5 , c R 2 = (CH 2 ) 2 O(CH 2 ) 2 + + 1 1' 3' 1 3 5 8 4 OH -Cl Cl --__________________________________________________________________________________________

No abstract

No abstract

Circadian rhythms of the intensity of 3H-melatonin absorption by organs of the hypothalamic-pituitary-thyroid system were studied in young mature male Wistar rats in summer. The hypothalamus, pituitary, and thyroid gland incorporated 3H-melatonin during the day and night hours, but the intensity of its incorporation in the pituitary and thyroid was high during daytime and low at night, while absorption of the hormone by the hypothalamus tended to be higher at night.