Ayurvedic phytomedicines are an hour requirement and more probable than allopathic medicines, which are not only pricey about "lead" but also linked to several negative side effects. The fruits of Withania coagulans exhibit notable anti-diabetic action, according to the ethnopharmacological usage and a literature assessment. A formulation incorporating the plant material was created after a thorough analysis of the powdered ethanolic extract of Withania coagulans fruits, making it more palatable and appropriate for diabetics. Pharmaceutical dosage formulations with a special dry plant extract and other components like talc, starch, and microcrystalline cellulose have been shown to have statistically significant anti-diabetic action. All of the values were within permissible limits, according to the findings of preformulation studies. The formulation's notable hardness and friability revealed that the tablets were mechanically stable. The formulation's disintegration took more than a minute. Significant results from an in-vitro anti-diabetic examination of a tablet formulation are evidence that the traditional Indian medical systems assertions regarding the effectiveness of this plant in the treatment of diabetes are true. The last inference made from the facts stated above is that since natural medicines do not have the substantial side effects associated with synthetic drugs, it may be appropriate to reconsider using these cost-effective, non-toxic, and plant-safe alternatives. The results of the preformulation studies showed that all of the values were within acceptable ranges.
Gold nanoparticles (GNPs) an emerging part of nanomedicine holds great promise for revolutionizing medical treatments and therapies in areas such as imaging, drug delivery, faster diagnosis, and tissue regeneration, as well as the development of new medical products. But their safety assessment is a major concern. As body system reacts in a different way than isolated cell line than artificial environment, so in the present experiment pathomorphological assessment ofsub-acute dermal toxicity of green synthesized GNPs and coating with Morinda citrifolia fruit extract (McFE) was undertaken. Gold nanoparticles were synthesized by biological reduction of chloroauric acid with Azadirachta indica (neem) 5% leaf extract. The nanoparticles characterized and were confirmed by colour changes from pale yellow to ruby red. These nanoparticles were coated with McFE.For toxicity evaluation.50 Wistar rats of either sex were assigned to five groups. One group was considered healthy, three groups received dermal application of combination of 1 mg/kg GNPs with 150mg/kg McFE (Low dose), 2mg/kg GNPs with 300mg/kg McFE (Medium dose) and 4 mg/kg GNPs with 600mg/kg McFE (High dose) dermal application for 28 days. The last group was considered as satellite group which received 8 mg/kg GNPs with 1200 mg/kg McFE and observed for extra 14 day beyond trial period for checking post withdrawal effect. Grossly mild hemorrhages, congestion and architectural alteration were observed in liver and kidney treated with highest dose. However the histopathological examination of skin revealed no alteration in skin architecture but minimal alterations were observed in liver and kidney where major changes like dilatation of central vein and sinusoidal space, multifocal necrobiotic changes and focal fatty change in liver and cystic degeneration and hyaline cast in lumen of kidney noticed indicating proper absorption and excretion of GNPs from body. K e y w o r d sSub-acute dermal toxicity, Morinda citrifolia, Pathomorphology in dermal toxicity, Gold Nano particles.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.