A lot of detrimental side effects on cancer treatment, causing lately, the focus of cancer treatment now shifted toward natural products such as medical plants. Sansevieria masoniana C are medical plants which have a high antioxidant content. This study aimed to evaluate the anticancer potential of Sansevieria masoniana C. extract with a fast prescreening method brine shrimp lethality assay (BSLA). This method measuring the LC50 of the of Sansevieria masoniana C. extract to the Artemia salina Leach Larvae that analog with the cancer cells. The result from Sansevieria masoniana C. extract shows that Sansevieria masoniana C. has potential anticancer activity with LC50 107,49 μg/mL. Sansevieria masoniana C. are products with excellent cytotoxicity and were promising sources for developing anticancer agents.
Sansevieria plants are known as ornamental plants that are able to ward off free radicals in nature, this plant allegedly potential as antioxidant. This study aimed to determine the antioxidant activity of three etanol plant extracts from Sansevieria genus, Sansevieria trifasciata, Sansevieria green tiger and Sansevieria zeylanica, were tested by using the 1,1-diphenyl-2-picryhydrazyl (DPPH) radical-scavenging assay. This method measuring the IC50 of the extracts. The plant extracts that point the highest antioxidant activity were Sansevieria trifasciata, the most potential as an alternative to antioxidant substitutes for vitamin C with an IC50 value of 9.44 ppm. This result would be promising sources for developing anticancer agents. Flavonoids are the principle elements for toxicity activity and are promising compounds for use as antioxidant agents.
Uncaria callophylla Blume ex Korth. is a wild plant species belonging to the Rubiaceae family. These plants thrive in the peat swamp forest of Kalimantan, Indonesia. The stems of Uncaria callophylla have been used by the Dayak Ngaju tribe to treat various diseases and to restore stamina while they work in the forest. The present study was conducted to identify the secondary metabolites in the methanolic extract of Uncaria callohylla stems to increase the knowledge about this plant and its potential in medicinal applications and drug discovery. The analysis was conducted using GC-MS and LC-MS/MS. GC-MS analysis was performed with the Agilent Technologies 7890 Gas Chromatography equipped with an Auto Sampler and 5975 Mass Selective Detector. The LC-MS analysis was carried out in the C18 column of the Waters Acquity UPLC system. MS analysis was performed with an electrospray ionization source (ESI) in positive and negative ion modes, and the compounds were identified using a UNIFI data processor with a mass spectrum library of natural active substances from the Waters Traditional Medical Scientific Library database based on UPLC/QTof MSE Data Acquisition. GC-MS analysis revealed the presence of 24 peaks, and nine of them showed quality 90% or higher, namely n-Hexadecanoic acid (16.63%), 1,3,7-Trimethyl-3,7-Dihydro-1H-Purine-2,6-Dione (13.07%), Hexadecanoic Acid, Methyl Ester; 1,2-Benzenedicarboxylic Acid, Diethyl Ester; 9,12-Octadecadienoic Acid, Methyl Ester; Methyl 14-Methylheptadecanoate; (9E,12E)-9,12-Octadecadienoic Acid; Z, E-3,13-Octadecadien-1-o1; and 2,6,10,14,18,22-Tetracosahexaene, 2,6,10,15,19,23-hexanethyl-, (all-E)-. LC-MS/MS analysis revealed the presence of five compounds, namely Arecatannin A1, Sweroside_2, Uncarine A, Epianhydrobelachinal, and Betulonic acid. All the secondary metabolites identified from GC-MS and LC-MS/MS analysis have biological activity, which indicates their medicinal potencies. From the result, it can be concluded that Uncaria callophylla stem methanolic extract contains various bioactive compounds justifies its traditional use, and therefore it can be developed further for new drug discovery.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2025 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.