In this work, nanomuscovite adsorbents were prepared via intercalation with different organic intercalates (DTAB- TTAB- DTPA- PA- PN). The prepared nanoadsorbents were used to evaluate the removal of Cd2+ and Pb2+ from polluted water. Best nanomuscovite was prepared by Muscovite with DTPA. The selected nanomuscovite was characterized by XRD, TEM, EDX, FTIR and BET surface area. The maximum Cd2+ and Pb2+ removal efficiency of the prepared nanomuscovite ( 91.5% Cd and 97% Pb ) was observed at intial metal concentration 50 ppm, pH 6 for Pb2+ and pH 7 for Cd2+, adsorbent dosage 0.2 g, contact time 60 min, and solution temperature 25oC. Isotherm models (Freundlich, Langmuir, Dubunin–Radushkevich and Temkin isotherm models) were applied for the adsorption of Cd2+ and Pb2+ on nanomuscovite adsorbent. The Langmuir isotherm model was well-fit by the adsorption of Cd2+ and Pb2+ on nanomuscovite. The kinetics of adsorption were validated using the pseudo-first order, pseudo-second order, Elovich, and intra-particle diffusion models.. Adsorption of Cd2+ and Pb2+ on nanomuscovite follows a pseudo-second order kinetic model in all four of the kinetic models. Thermodynamics parameters of Cd and Pb adsorption indicated exothermic and spontaneous processes for Cd2+ and Pb2+. The obtained results were applied to the real wastewater which indicated high Cd and Pb removal.