3D Printing or Additive Manufacturing is one of a novel method in manufacturing of materials with increased accuracy of manufacturing in terms of complexity in parts, design of aerospace and defense parts, light-weighting, etc., This manufacturing method involves layer-by-layer printing or deposition of materials or metals into the perfectly aligned especially in corners, edges and in most complex designs. The design process mostly involved software so that production cost could be estimated in the design stage itself. Additive Manufacturing is one of the most promising approach for small and low-volume productions. The filament used for the process is prominent to the designer, along with the various printing processes. Recent modern printing techniques involve multiple nozzles, whereas designers can use multiple materials on single printing. The use of multi-material in a single part enables the manufacturer to rapidly produce products which have specific applications. This chapter discusses about various multi-material with different mechanical properties that can be used for structural applications through different printing technologies on various precious applications. This technology is quickly adopted by even small-scale industries in recent times.