Changes in technique and growing experience of the multidisciplinary team improved operative and long-term results of bile duct injury repair.

Objectives-To analyse major histocompatibility complex (MHC) haplotypes in Mexican mestizo patients with seronegative spondyloarthropathies (SSpA) and normal controls, to discover if there are other antigens, besides B27, in the HLA region that might show association with the disease. Methods-The study included 100 Mexican mestizo patients with SSpA and 200 of their first degree relatives. These groups were compared with 85 ethnically matched controls. The class I and class III MHC antigens were obtained by standard methods. The significance of differences between patients and controls was tested by x2 analysis; linkage disequilibrium among the different alleles in each haplotype was estimated by computing delta values. Results-We found a significantly increased frequency of the HLA-B27 antigen (pcorr. = 1 x 10-5, odds ratio (OR) = 334, 95% confidence interval (CI) = 9-3-142.0).In the group of 45 SSpA patients negative for the B27 antigen, independent increased frequencies ofHLA-B49 antigen (Pcorr. = 0-03, OR = 6-5, 95% CI = 1-5-32-8)) and the FC31 complotype (pco,. = 0*04, [3][4][5][6][7]

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