A simple, accurate, precise RP-HPLC method has been developed and validated for the simultaneous estimation of Bromhexine HCl and Enrofloxacin in their combined tablet dosage form. The combination used for the Separation is ENROLIQ-B. Separation was performed on a C18 column [Hypersil BDS C18 column, 250 x 4.6 mm], with 0.05 M KH2PO4 Buffer pH 6: Methanol: Triethylamine (70:30:0.1 %v/v/v) as a mobile phase and flow rate was kept at 1 ml/min. Good sensitivity was found with UV detection at 261.00 nm. After method development the interference with the active compounds and excipients, repeatability and linearity were investigated. ReBROMtion times were found to be 3.190 and 5.067 min. respectively, for BROM and ENR. The method was validated over the analytical range from 1.5-4.5μg/ml for BROM (r 2 =0.998) and 20-60 μg/ml for ENR (r 2 =0.999). This method showed good reproducibility and recovery with %RSD in the desired range. The proposed method can be successfully applied for the routine analysis of both drugs in their combine dosage form.