PT. XYZ is a manufacturing company that produces medical devices. The company has planned to develop a new product called Medical Pharmaceutical Refrigerator (MPR). Based on research, the company has provided an area for MPR production of 648 m2. After analyzing the process, 5 areas are used in conjunction with other products, but one area called Polyurethane Injection produces a product flow mismatch in the PU area. This problem is solved by designing a layout using the Industrial Facilities method and Systematic layout planning with the Product layout approach. Based on the results of the study, proposed two alternative layouts which then analyzed the weight of material transfer using the From-to-chart method. Layout design 1 has a weight transfer material of 9322.09 per day, while the proposed layout design 1 produces a weight transfer material of 5750.5 per day. So, the MPR production layout is determined using the layout design 2. By determining this layout, a biomedical warehouse area was moved at of 49.42 m2.