Introduction: Solid waste management is a major issue in Nepal with Kathmandu valley generating the highest amount of solid waste. After recovery, the solid waste generated in Kathmandu valley is transferred to the Sisdol landfill site. There are waste workers in Sisdol landfill site who sustain their livelihood by collecting recyclables from those wastes. Personal protective equipment (PPE) is necessary to protect the frontline waste workers against infection. In addition, the waste workers need to know the proper usage of PPE in order to protect themselves from contamination. This study aimed to assess the awareness and proper usage of PPE along with the challenges faced by the waste workers at Sisdol landfill site. Methods: A descriptive cross-sectional study was conducted to collect data from landfill waste workers of Sisdol located at Kakani Rural Municipality in Nuwakot district of Nepal. A convenience sampling method was used based on the availability of landfill waste workers on that day and their willingness to participate. The data was collected using the structured questionnaire and personal interview of available waste workers. Results: The study comprised of 65% female and 35% male waste workers. The highest percentage of waste workers belong to 27-37 age group occupying 43% of total respondents.  Around 92% waste workers had participated in any orientation/training or session related to PPE and its usage. About 60% landfill waste workers were found only using mask and gloves. Conclusion: There is small number of waste workers who wish to wear full set of PPE. Most of them only like to wear mask and gloves. The gender, age group and the education level of waste workers had no association with the usage of PPE during the work.