Relevance. Despite scientific and technological progress and improvement of treatment methods, providing assistance for thermal burns of the skin remains a complex multicomponent problem. Extensive deep burns are not capable of self-healing, and therefore, over the past century, autodermoplasty has become the standard method of treatment. However, the shortage of healthy tissues of the patient often does not allow the transplantation to be performed in full, which entails the need to search for options for replacing auto-tissues.Intention. To present modern possibilities and evaluate the problems of using bioengineered skin substitutes in kombustiology.Methodology. Scientific literary sources published in recent years were searched for using the PubMed database and the platform of Scientific Electronic Library (eLIBRARY.ru ).Results and Discussion. Currently, many skin substitutes have been developed, ranging from single-layer tissue equivalents to artificial leather and genetically modified substitutes. However, all of them are still far from perfect, they have their advantages and disadvantages, which determine the features of their application and necessitate further research.Conclusion. The development of tissue equivalents of the skin has significantly improved the results of treatment of victims with deep burns and is a promising direction in the development of modern combustiology.

Breast cancer holds the leading position among womens cancer. Nowadays extensive experience has been acquired in surgical treatment of this disease. However, a significant proportion of young and middle-aged patients, the expansion of adjuvant therapy capabilities and the effectiveness of integrated treatment dictate a need to pay more attention to the aestheticity of surgical interventions. The review analyzes the results of the modern studies on the effectiveness and aestheticity of the most common types of surgical treatment of breast cancer; the evolutionary trends in oncosurgery are presented.