To determine the diagnostic parameters of the fuel system of engines of grain harvesters, technological and structural parameters of the technical condition were considered. The authors investigate the structural schemes of indicator connection of the purpose (performance) of the fuel system of engines and parameters of the technical state of its structural elements. For example, we consider the modal structure diagram, which characterizes the fuel system of grain harvester engines and parameters of the technical state of their structural elements. For example, we consider the modal structure diagram, which describes the fuel system of the engines. At the highest level there are parameters that describe the process of fuel supply and directly determine the characteristics of injection, or the law of fuel supply. On the lower levels there are parameters that characterize the technical state of the most important elements of the fuel equipment. They are used for elemental diagnostics. Experimental studies of vibration characteristics of nozzles of diesel engines have shown that the energy vibration nozzles manifested most actively at the frequency from 5 kHz to 10 kHz. Application of Hilbert's conversion to vibration analysis has made it possible to use the ability to control the identity of nozzles and identify defects, such as breakage of nozzles and spray gun hangs. When the injection pressure changes from 27.0 MPa to 8.0 MPa, signal duration, which is measured between the front and rear fronts with maximum amplitudes, decreases 2 times. Application of technological cards together with diagnostic means will allow in 1,5 times to cut down the technical equipment due to technical problems at expense of preventing bursts and reducing the fuel consumption by 5-10 %. The range of sensors for diagnostics of diesels, the basic electric circuit of the tool for measuring the angle are developed for fuel supply, the requirements for the computerized system for bench diagnostics of the fuel equipment.

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The literary review has established that to reduce the heat loss of a dryer, the heat insulation of the dryer design, heat recovery and suction air flow are used. However, the use of prospective suction airflow is not fully disclosed. In the article, based on the equations of mass transfer, thermal and material balance, the dependences of grain moisture and heat consumption on drying from the regime parameters of the dryer, grain properties, and air flow used during drying are found. Analytical dependencies are illustrated by the corresponding schedules. Analysis of the analytical and graphical dependences of grain moisture and heat consumption on the corn grain sample has established that reducing the heat consumption when drying the grain, possibly reducing the pressure in the dryer, while simultaneously draining the air stream before it is fed to the drying chamber.

Background. The treatment options for patients with multiple myeloma who refractory to previous bortezomib and lenalidomide therapy are limited. Pomalidomide is ап immunomodulatory agent that was registered for the treatment of patients with double refractory multiple myeloma.Aim. To evaluate efficacy, safety and optimal course of the therapy with pomalidomide in routine practice in patients with double refractory multiple myeloma.Materials and methods. Overall, 71 patients with double refractory multiple myeloma were included in the retrospective analysis. There were 36 males and 35 females. The median age was 61 years (range 35-79). According to Durie-Salmon staging system, there were 53 (79.1 %) patients in stage III, 13 (19.4 %) - stage II, and 1 (1.5 %) - stage I.The stage was unknown in 4 patients. Kidney impairment at the onset was in 10 (15 %) patients, the normal function was in 57 (85 %) patients and 4 patients had no data. Most patients (n = 68, 95.8 %) received pomalidomide in one therapy line, in 3 (4.2 %) patients - drug was given in two lines, totally 74 episodes of use. Median number of drugs prescribed prior to pomalidomide were 4 (2-9) drugs, including target ones - 2 (2-5). In the first remission 31 (43.6 %) patients received high-dose therapy with autologous stem cell transplantation. pomalidomide was administered in combination with low doses of dexamethasone (PomDex, n = 44; 59.4 %) and as a part of triple regimens (n = 30; 40.6 %). previously exposed (n = 22; 73.3 %) and new drugs (n = 8; 26.7 %) were used in the combination treatment. In 44 (61.9 %) patients pomalidomide was administered more than 3 years after the onset of the disease, median 63.5 (37-184) months. In 27 (38.1 %) patients it was given within less than 3 years after the onset, median 21 (6-36) months. The primary endpoint was progression-free survival. Secondary endpoints - pomalidomide tolerability, response rate and optimal third drug in the triple regimen. The dependence of progression-free survival, frequency of response and adverse events from the pretreatment, the choice of the third drug, gender, age, immunochemical variant, stage according to the International Staging System and to Durie-Salmon classification was studied.Results. The median time from the diagnosis to the start of pomalidomide therapy was 44.5 (6-184) months. The median of cycles with pomalidomide was 3 (1-30). The response was achieved in 52 (70 %) patients. The median progression-free survival was 4 (1-30) months, overall survival - 6 (0.5-42) months. Adverse effects were noted in 34 (46.5 %) patients. The most frequent adverse events were neutropenia grade III-IV (n = 14; 41.3 %), infection (n = 7; 20.7 %) and fatigue with limitation of daily activity (n = 6; 20.6 %). The rate of adverse events was higher in patients with triplets than doublets regimens of therapy: 43.3 % (n = 13) and 27.2 % (n = 12) respectively (p = 0.008). There were no statistically significant differences in progression-free survival between pomalidomide treatment options (two- or three-component regimen).Conclusion. Compared to the three-component therapy consisting of drugs to which refractoriness was previously diagnosed the PomDex scheme is less toxic and equally effective. Therapy with pomalidomide is effective in the majority of patients with double refractory multiple myeloma even in heavily pretreated. The toxicity is acceptable.