Objective. To optimize the treatment of pregnant women with a moderate form of COVID-19 by including a sorbent in complex therapy. Materials and methods. Pregnant women (n = 87) with a gestational term of 30 weeks or more were divided into 2 groups. Group 1 (n = 42) received standard treatment for COVID-19. Group 2 (n = 45) received an additional preparation of colloidal silicon dioxide. The following endotoxemia indicators were assessed: concentrations of C-reactive protein (CRP), interleukin-6 (IL-6), medium mass molecules (MМM). The course of pregnancy and complications of childbirth were evaluated. Results. At the peak stage of the disease, in patients of group 2 the level of МММ was 0,43 opt. units lower, CRP 7.1 mg / l lower, IL-6 2.3 ng / ml lower than in women of group 1. Anemia, fetal growth retardation, threatening preterm birth, fetoplacental insufficiency, polyhydramnios and oligohydramnios was diagnosed rarely in group 2; the average fetal weight was 256 g more, the average fetal height was 2.4 cm more than in group 1. In group 2, there were fewer children with moderate and severe asphyxia. Conclusions. The addition of colloidal silicon dioxide to the standard treatment of pregnant women with a moderate form of COVID-19 helps to reduce the level of endogenous intoxication, which is manifested by positive dynamics.