In order to identify risk factors and to study alteration of cerebral vessels in patients with type 2 diabetes mellitus and cerebrovascular disease, ultrasound Doppler investigation of extracranial vessels was performed in 67 patients with type 2 diabetes mellitus. Atherosclerotic lesions of the vessels were detected in 67% of patients, depending on age, gender, body mass index, duration of diabetes and hypertension, systolic blood pressure, cholesterol and blood glucose level fluctuations during the day. The number of vessels affected by atherosclerosis and a higher degree of carotid stenosis was significantly higher in patients undergoing brainstroke. Quality of life was significantly lower in patients with diabetes associated with cerebrovascular disease, especially in patients after brainstroke.

Российский медико-биологический вестник имени академика И.П. Павлова, №4, 2011 г. Ключевые слова: бронхиальная астма, метаболический синдром, абдоминальное ожирение, капнометрия. 93 ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ©

Aim to study the long-term results of surgical treatment of gastroesophageal reflux disease (GERD) in combination with hiatal hernia to optimize the selection of patients for surgical treatment. Materials and Methods. The study included 41 patients aged 24 to 71 years (mean age 49.9±4.95 years), operated for gastroesophageal reflux disease in combination with hiatal hernia Patients underwent the following surgery: laparoscopic fundoplication according to Toupet, laparoscopic fundoplication according to Nissen, partial fundoplication according to Chernousov. The following interventions were performed simultaneously with laparoscopic fundoplication in a number of patients: cruroraphy in 36 patients, cholecystectomy for gallstone disease in 10 patients and selective proximal vagotomy in 6 patients. Results. It is revealed that in the postoperative period subjective manifestations of GERD not always correspond to endoscopic degree of GERD. A body mass index is a reliable predictor of postoperative recurrence of GERD and hiatal hernia, that it is necessary to consider at selection of patients for surgical treatment. Conclusions. Operation of a laparoscopic Toupet fundoplication with a bilateral krurorafiya is associated with the best postoperative results. The selective proximal vagotomy in addition to anti-reflux operation authentically improves clinical result.

Aim. To determine the clinical and epidemiological characteristics of multiple myeloma (MM) in the Ryazan region in 2019. Materials and Methods. A retrospective analysis of medical histories of 107 patients with MM who were under observation at the hematology department of the state budgetary institution of the Ryazan region Regional Clinical Hospital (RCH) in 2019 was carried out. Registered morbid-ity implies identification of new cases of MM that were not registered before and were first de-tected in the current calendar year. Statistical analysis of the obtained data was carried out using Microsoft Office application programs and the methods of descriptive and parametric statistics. Results. In 2019, 107 patients of which 43 were men and 64 women aged 34-84 years (mean age 66.2±9.3 years), were under observation at the hematology department of the RCH. The ratio of men to women was 1.0 to 1.49, which reflects the all-Russian tendency. 3.77% Of patients with MM had IIA stage of the disease, 62.26% had IIIA stage, and 33.96% had IIIB stage of myeloma. The morbidity with MM in the Ryazan region in 2019 was 3.23 per 100 000 people. Conclusion. The incidence of the disease in the Ryazan region in 2019 was higher than the aver-age for Russia, which may be due to the diagnostic capabilities of the region with the existence of a specialized hematological department and an outpatient hematology service. In the age group of MM, patients aged 60-74 years predominated, women predominated in the gender structure. Among patients with MM in the Ryazan region, patients with III stage disease (96.22%) predominated.