The expression of prostate-specific membrane antigen (PSMA) on the surface  of prostate cancer  cells is increased with  tumor progression, which  is the  basis  for a theranostic approach in the  treatment of these patients. The PSMA ligand, labeled with the therapeutic radionuclide lutetium-177 (177Lu), delivers 177Lu beta particle radiation to PSMA-expressing prostate cancer  cells. Currently, PSMA-targeted radioligand therapy with  the  radiopharmaceutical  177Lu-PSMA-617 is  approved for  the  therapy of  patients with  metastatic castration-resistant prostate cancer  (mCRPC). We present a clinical  case  of successful use of this  method of treatment in our  center in a patient with  mCRPC,  progressing after  two  lines  of therapy — hormone therapy with  new generation of androgen signal  inhibitors (abiraterone, enzalutamide) and  chemotherapy with docetaxel.

This review, using illustrative examples, shows the possibilities of using bone scintigraphy as a basic method for examining patients with osteosarcoma in accordance with the most significant international and domestic recommendations. The material is based on many years of experience and our own database of more than 1000 observations. The possibilities of other radionuclide diagnostic techniques in the diagnosis and monitoring of patients with osteosarcoma in solving various clinical problems are shown. The expediency of using three-phase osteoscitigraphy is based on the examination of 95 patients in dynamics. Radionuclide diagnostics has not lost its importance in the diagnosis of osteosarcoma and its metastases and continues to be in demand among pediatric and adult oncologists.

Modern nuclear medicine is a rapidly developing field that includes various non-invasive molecular imaging techniques with the ability to examine the whole body.Inflammation is a frequent complication in surgical and traumatological practices, which is a complex, local and general pathological process that occurs in the body in response to injury. Having arisen under the influence of a damaging factor, inflammation is characterized by the development of a dynamic complex of changes. However, the search for inflammation foci of inflammation by traditional diagnostic methods in some cases is difficult even with a detailed clinical picture. In this case, nuclear medicine, which is able to visualize pathological processes, including those with a pathological increase in metabolism, may be the best option for finding the affected area.A wide variety of radiopharmaceutical drugs makes it possible to determine the localization of the inflammatory focus in a short time and with high accuracy and makes nuclear imaging methods a priority for the early diagnosis of pathophysiological reactions.This paper presents a review of domestic and foreign literature on the use of specific and nonspecific radiopharmaceuticals in the diagnosis of inflammation. Own cases is also presented.

Purpose: To show the additional clinical importance of SPECT/CT method in the complex diagnosis of skeletal system.Material and methods: Patient: male, 75 years. Medical history: At the beginning of July 2021 the patient noticed the presence of blood in urine, and after that he seeked medical assistance from urologist. During medical check up — suspicion on prostate tumor. 09.07.21 PSA > 100 ng/ml. The patient was directed to N.N. Blokhin National Medical Research Center of Oncology for further examination and treatment. Whole body bone scan revealed multiple foci of increased activities of the radiopharmaceutical in the lumbar spine, sacral vertebrae and in the projection of groin and scrotum. After bone scan, SPECT/CT was performed. Metastatic lesions of bone tissue were not confirmed, however, an inguinal scrotal hernia and a nodus in the pelvic cavity (probably of a metastatic) were detected.Conclusion: The use of SPECT/CT made it possible to detect additional changes in the study area. Information about the presence of an inguinal hernia will help prevent complications.

No abstract