Оптимизация лечения Эпштейна-Барр вирусного инфекционного мононуклеоза у детей В. Б. КОТЛОВА, С. П. КОКОРЕВА, А. В. ТРУШКИНА ГБОУ ВПО «Воронежская государственная медицинская академия имени Н. Н. Бурденко» Министерства здравоохранения Российской Федерации, БУЗ Воронежской области «Областная детская клиническая больница № 2», Воронеж, РФ В работе представлены результаты наблюдения за 103 детьми в возрасте от 10 месяцев до 15 лет с ВЭБ-ассоциированным инфекционным мононуклеозом (ИМ), обусловленным в 32% острой первичной Эпштейна-Барр вирусной инфекцией (ОЭБВИ) и в 68% случаев реактивацией хронической (ХЭБВИ). Выявлены клинико-лабораторные особенности течения ИМ в зависимости от формы инфекции. В исходе ИМ при первичном инфицировании в 5,8 раза чаще, чем при ХЭБВИ, через год после перенесенного заболевания формируется латентная инфекция. Показана высокая эффективность монотерапии рекомбинантными интерферонами при первичной инфекции и обоснована целесообразность комбинированной этиотропной терапии при лечении ХЭБВИ. Ключевые слова: Эпштейна-Барр вирусная инфекция, дети, рекомбинантные интерфероны, индукторы эндогенного интерферона The paper presents the results of observation of 103 children aged from 10 months to 15 years with EBV-associated infectious mononucleosis (IM), determined in 32% by acute primary Epstein-Barr virus infection (AEBVI) and in 68% of cases by reactivation of chronic Epstein-Barr virus infection (CEBVI). Clinical and laboratory characteristics of the course, depending on the form of infection, were investigated. As a clinical outcome of infectious mononucleosis in patients with primary infection latent infection after a year is formed 5.8 times more often than in patients with chronic Epstein-Barr virus infection (CEBVI). The high efficiency of recombinant interferon monotherapy in patients with primary acute infection was recorded and the expediency of combined etiotropic therapy in the treatment of chronic Epstein-Barr virus infection was found out.

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The typewritten “Reporting Collection of Poems by the Group of Irkutsk Poets for 1921” is published for the first time in its entirety. This example of early Soviet literary “samizdat” represents the works of twelve members of the local literary association “The Barque of Poets” (Barka poetov): Sergei Arkadievich Alyakrinsky (1889–1938), Artur Ancharov (whose real name and fate remain unknown), Viktor Mikhailovich Blumenfeld (1897–1978), Alexander Ivanovich Venediktov (1896–1970), Mikhail Nikolaevich Gorin-Volkov, who wrote under the pseudonym “Imray” (1894–1942), Alexander Davidovich Meiselman (1900–1938), Nina Mikhailovna Podgorichany-Petrovich (1889–1964), Igor Kronidovich Slavnin (1898– 1925), Elpidifor Innokentyevich Titov (1896–1938), Leonid Dmitrievich Tyazhelov (1887–1936), Nina Pavlovna Shastina (1898–1980) and Nina Petrovna Komarova (1892 – after 1943), who wrote under the pseudonyms “Nibu” and “Khabias”. In addition to the “Reporting Collection...” itself, some accompanying materials are also published (a questionnaire for members of “The Barque...” and several poems on separate sheets). All these materials of the early Soviet “samizdat” were kept in private archive of Irkutsk professor Boleslav Sergeevich Shostakovich (1945–2015), and after his death they were transferred to the State Archives of the Irkutsk Region. The publication is provided with bio-bibliographic references about the authors of the “Reporting Collection...”, both brief (in the cases of such well-known poets as Igor Slavnin, Elpidifor Titov or Nina Khabias) and, if necessary, expanded.