Data on the isolation and structure determination of cycloartane glycosides cycloorbicoside G from Astragalus orbiculatus Ledeb. and cyclosieversioside A from A. sieversianus Pall. roots are presented. Preparations administered per os to male rats at a dose of 10 mg/kg increase the energetic potential of myocardium, contribute to inhibition of peroxide oxidation of lipids, and stabilize antioxidant and NO-ergic systems. A positive effect on myocardium metabolism was especially evident in rats with adrenaline myocarditis.We have previously reported a positive influence of certain cycloartane glycosides on metabolic processes in myocardium [1]. In continuation of research in this area, we studied the influence of two new cycloartane glycosides cycloorbicoside G and cyclosieversioside A that were isolated from plants of the genus Astragalus on energy exchange, peroxide oxidation of lipids (POL), and interrelated changes of antioxidant and NO-ergic systems in myocardium of normal animals and those with adrenaline myocarditis.

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