The questions of negative impact of infrasound in conditions of urban territory of city district Samara are considered. Analysis of sources of infrasound radiation have been carried out. Peculiarities of the negative impact of infrasound are considered. Results of measurements of infrasound are allowing to conclude that there is exist exceeding of normative values of infrasound in a number of zones of living territory of city district Samara. It is necessary to develop and to implement the measures for reduction of negative impact of infrasound.