We have developed a new method for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones in
good to excellent yields via phosphomolybdic acid (PMA)-catalyzed cyclocondensation of 2-
aminobenzamides with aldehydes or ketones in N,N-dimethylformamide (DMF) at room temperature.
The present method proves to be efficient in terms of short reaction time, high yield, simple workup
and easy purification.
A novel, efficient, and practical approach for the synthesis of benzofuran‐2‐carboxamides has been developed through the base‐promoted tandem intramolecular cyclization and hydrolysis of 2‐formylaryloxyacetonitriles at room temperature. This method provides a convenient route to benzofuran‐2‐carboxamides in up to 98% yield with favorable functional group compatibility. A gram‐scale reaction was also performed to demonstrate the scaled‐up applicability of this methodology.
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