In the structure of mycosis pathologies of birds, the top place is occupied by aspergillosis. The main pathogenicity factor is Aspergillus spp., which quickly penetrates the lungs' alveoli and causes a pathological process. Because the level of the fodder base contamination with fungi of the genus Aspergillus is quite significant, an essential link in the technological process of growing young poultry is to prevent contamination and increase the economic efficiency of production. The paper examines the effectiveness assessment of grain treatment with natural disinfectants in the framework of aspergillosis prevention in poultry farming. Moreover, the advantages of using natural disinfectants for their use in modern eco-production of animal-origin products are described in the paper. Antifungal properties of infusions of medicinal plants are due primarily to the presence of biologically active substances synthesized by the plant. Black walnut and walnut (leaves and fruits of milk-wax and full ripeness), rosehips (dried fruits and roots), carnation (fruits), calendula (flowers), turmeric, chamomile (flowers) were used as the studied plants for the disinfectants production. The shortcomings of the existing synthetic means used in poultry farming are emphasized separately. In particular, phenolic resins have heterogeneous antifungal activity against fungal spores and are incompatible with some detergents. It was found that there is a significant difference in the number of live birds after 30 days of feeding grain treated with various disinfectants and when feeding grain without prior treatment. Thus, for group 1, which was fed grain treated with an infusion of walnut fruits and leaves, the absence of Aspergillus fumigatus fungi was noted even after 30 days of feed treatment. A similar result was obtained after processing grain with an infusion of black walnut fruits or leaves. In group 2, the control group, a significantly higher degree of withdrawal of young birds caused by aspergillosis was observed. The medicinal plants selected also did not demonstrate satisfactory results in all cases because turmeric infusions from the fruits and roots of rosehips and calendula flowers did not demonstrate a sufficient indicator of effectiveness. On the 20th day after grain processing, Aspergillus fungi were recorded in the samples. Further research on the effect of medicinal plant infusions on the fodder base of various types of poultry is promising because the prevention of aspergillosis is more economically feasible than the treatment of sick young animals.

The article presents the results of clinical studies of domestic cats and dogs with diabetes mellitus on the background of obesity at the beginning and for a month of treatment. Domestic cats with diabetes were prescribed active exercise and industrial diet Royal Canin Diabetic Feline, dogs – Royal Canin Diabetic DS37. The portion size was determined according to the manufacturer's recommendations. Treatment of small animals for obesity, both alimentary and endocrine, preferably involves feeding food in limited quantities to cause controlled weight loss, as well as increased physical activity, which can provide additional energy expenditure. Successful weight loss can reduce the effects of comorbidities associated with obesity, such as improved mobility in osteoarthritis, increased insulin sensitivity and the reversal of other metabolic disorders, and improved quality of life. The main pathogenetic therapy for animals with diabetes for both domestic cats and dogs is the mandatory use of insulin. Researching the market of drugs in Ukraine, we chose the most affordable and effective veterinary drug – Caninsulin. The dose of insulin was selected individually for each animal by plotting a curve of blood glucose concentration over three days. At the beginning of treatment and at the end of the course, we conducted a comprehensive study of animals of both species. In cats, the general condition significantly improved as a result of treatment: only one animal remained depressed, the number of cases of hyporexia decreased, only 25.0 % of animals remained pale mucous membranes; temperature within the physiological norm; vomiting and bradycardia were not reported. A decrease in the rate of shortness of breath and drowsiness also indicates an improvement in the condition of cats with obesity due to diabetes. The improvement of the general condition of domestic dogs is evidenced by the restoration of the condition of the coat (about 4 times), the restoration of appetite in 66.7 %. Only one dog had anemia of the mucous membranes. Anxiety, bradycardia, hypothermia and itching disappeared completely. Within one month, there was a tendency to decrease the body weight of animals of both groups, but due to the insufficient duration of treatment, their fatness still remained excessive. Which indicates the need for further correction of the pathological condition.

It has been established that the most common mycoses among poultry are aspergillosis and mucormycosis, which are observed in sporadic cases under conditions of violation of egg incubation technologies, zoohygienic conditions for poultry keeping, and feed storage. Aspergillosis (pneumomycosis, brood pneumonia, mycosis) is an infectious disease that most often affects the respiratory system and, less often, the serous membranes of other organs, namely the liver, intestines, spleen, kidneys, central nervous system, and air cavities of the tubular bones. Aspergillosis affects all species of poultry and wild birds. The disease is more common in young animals in the first days of life. In the studied poultry farms, aspergillosis has a different intensity. The disease can kill 30 to 50 % of all young animals and, in some cases, only a few. This is due to the infection of the fungus in the environment, its pathogenicity, the bird's age, and its resistance. The material for the research was carcasses and aspergillosis-sick birds from Poltava HPE LLC, Poltava Poultry Factory JSC, Poltava Incubator Agricultural Complex, and Poltava district private farms. Statistical indicators from the surveyed farms and micro-sections. It has been established that the causative agent of aspergillosis in chickens and young guinea fowl is mainly the fungus Aspergillus fiimigatus, less often Aspergillus flavus. Sources of infection in the surveyed farms are infected hatching eggs infected with fungal spores and moldy litter. Determining factors contributing to the infection are unsatisfactory conditions for keeping young birds: high humidity and faulty ventilation system. Chickens are more sensitive to aspergillosis than young guinea fowl because, for chickens, the number of detected pathologies in various organs and systems is much higher. The disease in chickens is superacute, acute, and chronic; in young guinea fowl, it is in a mild form (without chronic forms). Clinical signs of avian aspergillosis are not typical, which complicates the lifelong diagnosis of the disease. The results show that raising guinea fowl is a more profitable business because the rate of loss of young is much lower than that of chickens and the rate of sexual maturity for guinea fowl is also higher. Aspergillosis in one-three-day-old chickens is characterized by serous tracheitis, bronchitis, aerosacculitis, and serous fungal pneumonia. Histological examination of the lungs showed swelling of endothelial and alveolar cells, the presence of fungal spores in blood vessels, necrosis, and desquamation of the respiratory epithelium.