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The noncompetitive DNA hybridization and conductivity in the presence of non-charged ligands have been investigated and the comparison is made with the ligand-free case. It has been shown that the intercalating ligands enhance the sensitivity of the DNA chips as compared with the ligand-free case at the high enough concentration of ligands.

The general formalism describing polyelectrolyte behavior in presence of sequence disorder is presented. The Edwards and Poisson–Boltzmann equations are obtained. The possible effect of the boundary conditions is discussed. Comparison between replica and constrained annealing approaches is made.