Aim. To assess the results of the integrated treatment of women with recurrent chronic cystitis using the selective 3-adrenoreceptor (AR) agonist, mirabegron. Methods. The results of the treatment of women diagnosed with recurrent chronic cystitis in the urological clinic of KSMU were analyzed. The average age of patients was 31.53.4 years. To assess the effectiveness of integrated treatment, women with recurrent chronic cystitis were randomly divided into two groups: the first group (30 patients) who received antibiotic therapy in combination with the drug mirabegron at a dose of 50 mg once a day and the second (control) group (30 patients), who received antibiotic therapy taking into account their susceptibility. All patients underwent ultrasonography of the genitourinary system, urodynamic studies with assessment of the maximum urinary flow, average urinary flow, bacterial urine cultures. Results. Analysis of the research results showed a greater reduction in the number of urinations per day (up to 7 times) in the first group. The frequency of urinary urgency decreased in 82.6% of the first group patients compared to 64% of the second group (p 0.05). In the combination therapy versus control groups, there was reduced hospital stay by an average of 4 days (11.2 vs 15 days; p 0.05). On the 15th day of treatment, control cystoscopy revealed no changes in the bladder mucosa in all patients of the first group. Also, in the first group of patients, there was a greater improvement in urodynamic parameters compared to the control group (p 0.05). Conclusion. The selective 3-AR agonist mirabegron used in the integrated treatment of recurrent chronic cystitis increases the effectiveness of the therapy.

Inflammation of the prostate gland occupies a significant proportion of inflammatory diseases of the genitourinary system. According to J.Potts et al. (2007), prostatitis is detected in 510% of the general male population. Today, one of the main problems associated with prostatitis is the narrowly targeted, often unwarranted treatment with its antibacterial drugs without taking into account the multifactorial nature of the pathogenesis and androgen dependence of the prostate gland. As a result, this leads to ineffective treatment of prostatitis amid growing antibiotic resistance. In turn, recent studies demonstrate key issues of testosterone and prostate gland relationship. These researches show that prostate metabolism is dependent on testosterone levels. The level of the hormone affects the course of chronic inflammation in the prostatic tissues. And also, that the number of bacterial agents that provoke pathological processes in the prostatic parenchyma directly depends on the degree of decrease in testosterone levels. This point of view is also supported by other studies. It was found that most patients with inflammation of the prostate gland had androgen deficiency, and correction of testosterone levels of these patients was highly effective in the treatment of chronic prostatitis. Thus, the androgen dependence of the prostate gland and the effect of hypogonadism on the incidence of prostatic parenchymal inflammatory changes allow us to radically revise the approach to the diagnosis and treatment of chronic bacterial prostatitis. The development and implementation of new algorithms in which the diagnosis and subsequent correction of concomitant androgenic are becoming a promising direction for this group of patients.

The formation of intestinal urinary bladder with the recovery of physiologic principles of the uresis is the most rational from the point of view of medicosocial and working rehabilitation of patients suffering from urinary bladder cancer after cystectomy. The variations of extraperitoneal and intraperitoneal situs of intestinal transplant are determined depending on the character and stage of cystectomy. The developed method of one and many-stage formation of intestinal urinary bladder permits to extend the possibilities of its performance in patients after cystectomy.

The transperioral biopsy of the prostate under sonographic control is performed in 13 patients. The urinary bladder carcinoma is revealed in 4 patients and adenocarcinoma is revealed in 9 patients. The transcutaneous paracentetic nephrostomy under ultrasound control being an effective method of supravesical urine lead is performed in 23 patients with retentional and obstructive affection of upper urinaiy tracts as a result of the urinary bladder tumor invasion. The interventional ultrasound tactics in patients with tumors of the urinary bladder and prostate is perspective.

Background. Chronic cystitis is the dominating urinary tract disease. Due to its high prevalence among women, this issue remains topical in medicine. Aim. To evaluate the effectiveness of the sodium hyaluronate in the complex treatment of chronic recurrent cystitis. Material and methods. The research included 60 patients with a confirmed clinical diagnosis of chronic recurrent cystitis in the clinic of Kazan State Medical University for the period from July 2020 to July 2021. To evaluate the effectiveness of treatment, the patients were divided into groups using the copy-pair method. The first (main) group included 30 women receiving anti-inflammatory therapy and local treatment with collargol instillations. After that, the patients were prescribed the topical use of sodium hyaluronate: 40 mg (50 ml) once a week for 1 month. The second (control) group also included 30 patients who received only anti-inflammatory therapy and local treatment with collargol. The average age of the observed patients was 30.51.5 years: in the first group 31.11.5 years, in the second group 31.91.3 years. All patients underwent control cystoscopy, ultrasound and urodynamic examinations on the 15th and 30th day of treatment. The Welch's t-test, Fisher's test, analysis of variance with repeated observations were used as statistical data analysis methods. Results. Treatment was completed by all patients in both groups. The patients management showed a significant decrease in the number of urination (up to 6 times a day), and urgent uriesthesia was recorded in 86.6% of women in the main group compared to 60% in the control group (p 0.05). The control cystoscopy performed on the planned 15th day of treatment showed positive dynamics in the bladder mucosa recovery under the collargol influence. All patients of the first group had no changes in the mucous membrane of the bladder. There was a positive dynamics of urodynamic parameters in the first group compared to the control group. Conclusion. The sodium hyaluronate, which was included in the complex therapy of chronic recurrent cystitis, accelerates the process of the bladder mucosa regeneration after local treatment with collargol and reduces the time of its recovery.