BACKGROUND: Coronary Heart Diseases (CHD) is one of the leading causes of death worldwide. Proper management for CHD patients is needed to reduce mortality. Nurses have a very important role in making CHD patients can carry out optimal health behaviors. AIM: This review study aims to identify the effect of the nurse-led program on CHD patients. METHODS: This systematic review was based on four electronic databases (Scopus, Science Direct, ProQuest, SAGE Journals) and published between 2011 and 2020. This review used the Joanna Briggs Institute and Prisma guidelines. The study’s eligibility was assessed from the title, abstract, research methodology, and full text. The review results were presented in tabulated data and narrative form. RESULTS: Nine articles showed that the nurse-led program significantly improved health behavior, health-related quality of life, clinical outcome, and illness perception in CHD patients. CONCLUSIONS: It is expected that the improvement of management in CHD patients will improve patients’ quality of life. Hence, it could reduce the number of morbidities and mortality.