The Rector’s Office Building of Syiah Kuala University is the administrative headquarters at Syiah Kuala University which has a high density schedule. Employees in the building, work for 8 hours a day in the building. Staying in a room for an extended period of time can lead to disease, particularly Sick Building Syndrome (SBS). Poor air quality as a result of air pollution and poor air exchange is the primary cause of SBS. Therefore, it is important to evaluate the air quality in the room to prevent SBS. This research was conducted with a quantitative approach by measuring the physical and chemical quality of the indoor air. The study was conducted on two sample rooms, namely the administration room and the student affairs office. The method of collecting data is descriptive by evaluating based on the regulations of the minister of health and SNI. Air quality is also seen based on the results of room simulations using ANSYS 2019 R3. Based on the results of field measurements, the air quality in the room is not good. Thus, 60% of the employees in the Administration Room and 64.71% of the employees in the Student Affairs Office were infected with SBS.

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