Introduction: Uncontrolled diabetes leads to increased risk of complications. Inammation is believed to have a role to greater extent, in the pathogenesis of complications of type 2 DM. Also Inammation (as predicted by inammatory markers) and chronic hyperglycaemia (as predicted by Glycated Haemoglobin (HbA1c) ) jointly contribute to the cardiovascular risk of patients. Hence this study was done to correlate markers of inammation which can be estimated readily (like hsCRP, serum ferritin and ESR) with glycaemic control (HbA1C) and understand the relationship between them. Material And Methods: A prospective cohort study was done in 70 adult patients with diabetes mellitus during December 2021 to September 2022 after taking informed consent from patient. Patients on medication which reduce CRP levels were excluded. Patients with heart failure, acute febrile illness, renal, hepatic & malignant disorders, chronic illnesses, asymptomatic infections and smokers were also excluded from the study. Patients were selected by purposive sampling method. A semi-structured questionnaire was used to record patients data, and ndings of examination and investigation. Based on HbA1C patients were grouped as good control (HbA1C <6.5%) and poor control (HbA1C ≥ 6.5%) and comparison was done. Data entered in Microsoft excel 2013 and analysed using SPSS version 22 package. Pearsons correlation coefcient, T test and chi-square test was used for statistical analysis. P < 0.05 was considered to be signicant statistically. Results: The mean age of the study patients was 51±23.1 years with male to female ratio being 48:32. HbA1C was ≥ 6.5% (poor control) in 50 patients and <6.5% in 20 patients which shows that diabetic control was good in only 20 patients. Mean ESR, serum ferritin and hsCRP was signicantly more in patients with poor diabetic control. Pearson's correlation of HbA1C versus ESR (R = 0.654, P <0.001), serum ferritin (R= 0.22, P value = 0.006) and hsCRP (R=0.685, P<0.001) of all the study participants was highly signicant. Conclusions: Inammatory markers like ESR, hsCRP and serum ferritin are positively correlated with high HbA1C levels or poor diabetic control. Other factors associated with poor diabetic control includes, increasing age and BMI
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.