Sustainable coexistence of different components of an ecosystem is a fundamental requirement for the overall welfare of the human population worldwide. Despite this fact, continued growth in human population, increasing demand for various available natural resources, and invasion of all inhabitable habitats have led to the destruction of the coexistence of wildlife and human and also caused the fragmentation of natural habitat for the wildlife in India. This in turn may viciously affect the rural population residing in the nearby area of such regions, for example, the area covered for sanctuaries, which are established in consideration to provide protection to the indigenous wildlife. Hence, it becomes essential to mitigate such conflicts to create a healthy environment for cosurvival of all stakeholders. Here, in this study, we have tried to figure out the possible reasons and provide certain cures to avoid the recurring human-wildlife conflicts in one of the largest wildlife sanctuaries, Hastinapur wildlife sanctuary, situated in Uttar Pradesh, India.