Lymphoma is the third most common cancer worldwide. Oral cavity Lymphoma forms 3% of all lymphomas in the general population. This is a case report of non Hodgkin B-cell lymphoma in 60 -year-old black male who was diagnosed earlier as having benign lympho-epithelial lesions of salivary and lacrimal glands. The patient was complaining of painless symmetrical facial swelling of the parotid, submandibular and lacrimal glands. Serological findings were negative for antinuclear antibody (ANA), anti-SS-A and anti-SS-B antibodies. Bilateral surgical excision of disfiguring buccal swollen salivary gland revealed a B-cell lymphoma. Chemotherapy started and dramatic response was noticed with total disappearance of all lacrimal and salivary gland swelling.