BACKGROUND: Osteoporotic bone marrow defect of the jaw is an uncommon localized radiolucency that consists of hematopoietic red marrow with varying amounts of fatty yellow marrow. The lesion is usually asymptomatic and accidentally discovered during a routine radiographic examination; however, some studies showed different results. CASE REPORT: This is an uncommon case of bilateral mandibular osteoporotic bone marrow defect in a 40-year- old healthy female. One of the defects reoccurred, and it involves dental implants. PLAN OF TREATMENT: Lesion was managed by curettage and the patient was followed up after 1,6,12 months. CONCLUSIONS: in order to diagnose FOBMD and differentiate it from other lesions, further researches are needed to help fully understand it, since the exact incident and etiology are not established yet.

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