The condition known as type 1 diabetes mellitus (T1DM) results in absolute insulin deficiency due to autoimmune-mediated and idiopathic destruction of beta cells in the pancreas. 1 STZ is a glucosamine nitrosourea compound (a 2-deoxyd-glucose derivative of N-methyl-N-nitrosylurea). 2 It has diabetogenic properties that result in the selective destruction of β cells. STZ has been successfully used to induce diabetes in mice, rats, monkeys, guinea pigs, hamsters, dogs, and cats. The clinical and pathologic changes in animals treated with