Ulcer constitutes loss of tissue involving the whole epithelium, that may affect connective tissue. It has typical features: central crater, relieved edges, yellow area. This primary lesion may be a sign of various diseases of the mouth, whose diagnosis might be quite challenging, because may range over many conditions like traumatic lesions, inflammatory diseases, infections, cancer, autoimmune diseases, topical application of drugs. To find a diagnostic classification it's important to recognize ulcers in acute or chronic, multiple or solitary, symptomatic or not. The authors report the case of a 46 year old man who presented at Martini hospital in Turin with the main complaint of the presence for 5 months of a asymptomatic exophytic ulcerated lesion of the oral mucosa, treated by the authors with complete excision and placement of PRF and medicated gauze.