Potential bis-intercalating compounds N,N-dibenzylidene-N2,N2'-(pyridine-2,6-dicarbonyl)- di(aminoacidhydrazides) 4a-4j, N,N'-substituted pyridine-2,6-bis(carbohydrazides) 5a-5d and N,N'-substituted N2N2'-bis(pyridine-2,6-dicarbonyl)di(aminoacidhydrazides) 6a-6g, both racemic and optically active, can be easily synthesized from pyridine-2,6-bis(carbohydrazide), natural amino acids and aromatic aldehydes or anhydrides of aromatic ortho-dicarboxylic acids.

Dinicotinic acid reacted with L-phenylalanine affording N-dinicotinoyl-bis-L-phenylalanine (VII). The same product was also obtained by mild alkaline hydrolysis of the corresponding ester VI. Coupling of VII with L-ornithine or L-ornithine methyl ester gave rise to the formation of the desired chiral bicyclic tripeptides IIIa and IIIb as enniatin analogues.

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