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This work aims to evaluate the effect of the organic extracts of Bunium incrassatum roots on some hematological parameters and histological changes of the genital tract. The study was achieved on mature rabbits of the local breed for 15 days. The animals were divided into five groups, which have daily administered 0, 25, 50, 100 and 200 mg/kg/day doses, respectively.The group with dose 0 was taken as a control. After treatment, the rabbits were sacrificed. The rabbit blood was collected in heparin tubes and their ovaries and uterus were removed, fixed in 10 % formalin; and stained with hematoxylin-eosin. The treatment induces a significant decrease in the level of Triglyceride, Cholesterol and a significant increase in the number of growing follicles accompanied by a decrease in atretic follicles, compared to the control group. The study shows that the organic extract of B. Incrassatum has estrogenic effects.