This study aimed at determining the impact of the novel COVID-19 disease on Jordanian university students, from their own perspectives, and exploring if there were statistically significant differences in this impact due to the following variables: university, gender, faculty, age, residence, birth order in family, and education level.The study adopted the descriptive survey approach. The data was collected through a questionnaire of which the validity and reliability were proven. The convenience sample comprised 3269 students from among 326910 students that formed the survey population.  The results revealed that the degree of the impact of COVID-19 on Jordanian universities' students, from their own perspectives, was high. The degree of the psychological and social impact was medium, whereas the degree of the economic, and educational impact was high. The results revealed that there were statistically significant differences in the impact due to various factors: 1) type of university, where students in private universities were more impacted; 2) gender, where females were more impacted; 3) faculty, where humanities students were more impacted; 4) residence, where camp residents were more impacted; and 5) education level, where bachelor's degree holders were more impacted.In the light of the results of the study, the researchers present some recommendations to alleviate the negative impact of COVID-19 on Jordanian universities' students.